sch 79797 Search Results


sch 79797 dihydrochloride  (MuseChem Chemicals)
N/A
SCH79797 dihydrochloride(CAT: M031092) is a synthetic small-molecule antagonist of the human protease-activated receptor-1 (PAR1), a G protein–coupled receptor involved in thrombin-mediated platelet activation, vascular tone, and inflammation. By selectively blocking PAR1 signaling, SCH79797 inhibits platelet
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sch 79797 dihydrochloride n 3 cyclopropyl 7 4 1 methylethyl phenyl methyl 7h pyrrolo 3 2 f quinazoline 1 3 diamine dihydrochloride  (Tocris)
94
Tocris sch 79797 dihydrochloride n 3 cyclopropyl 7 4 1 methylethyl phenyl methyl 7h pyrrolo 3 2 f quinazoline 1 3 diamine dihydrochloride
Sch 79797 Dihydrochloride N 3 Cyclopropyl 7 4 1 Methylethyl Phenyl Methyl 7h Pyrrolo 3 2 F Quinazoline 1 3 Diamine Dihydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sch+79797/SCH+79797+dihydrochloride/pmc01855055-34-139-148
Average 94 stars, based on 1 article reviews
sch 79797 dihydrochloride n 3 cyclopropyl 7 4 1 methylethyl phenyl methyl 7h pyrrolo 3 2 f quinazoline 1 3 diamine dihydrochloride - by Bioz Stars, 2026-09
94/100 stars
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par1 antagonist sch79797  (Tocris)
93
Tocris par1 antagonist sch79797
Figure 1. Protease‑activated receptor‑1 <t>(PAR1)</t> activation-dependent expression of epithelial‑mesenchymal transition (EMT) markers in MKN45/PAR1 and MKN74 cells. Whole‑cell and nuclear‑cell lysates of MKN45/mock, MKN45/PAR1 and MKN74 cells were probed for EMT‑marker expression by western blotting. (A) EMT‑marker expression remains the same in MKN45/mock cells treated with α‑thrombin or α‑thrombin plus <t>SCH79797</t> for 24 h. (B) MKN45/PAR1 and MKN74 cells treated with α‑thrombin present decreased levels of E‑cadherin and β‑catenin and increased levels of fibronectin and vimentin in whole‑cell lysates over time. Nuclear lysates of these α‑thrombin‑treated cells presented an increase in β‑catenin over time suggesting movement of β‑catenin into the nucleus. (C) When treated with α‑thrombin and SCH79797, MKN45/PAR1 and MKN74 cells present results similar to MKN45/mock cells. Equal loading of protein was confirmed with anti‑GAPDH antibody.
Par1 Antagonist Sch79797, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sch+79797/SCH+79797+dihydrochloride/pm25231630-15-2-13
Average 93 stars, based on 1 article reviews
par1 antagonist sch79797 - by Bioz Stars, 2026-09
93/100 stars
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sc 203693a  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology sc 203693a
Figure 1. Protease‑activated receptor‑1 <t>(PAR1)</t> activation-dependent expression of epithelial‑mesenchymal transition (EMT) markers in MKN45/PAR1 and MKN74 cells. Whole‑cell and nuclear‑cell lysates of MKN45/mock, MKN45/PAR1 and MKN74 cells were probed for EMT‑marker expression by western blotting. (A) EMT‑marker expression remains the same in MKN45/mock cells treated with α‑thrombin or α‑thrombin plus <t>SCH79797</t> for 24 h. (B) MKN45/PAR1 and MKN74 cells treated with α‑thrombin present decreased levels of E‑cadherin and β‑catenin and increased levels of fibronectin and vimentin in whole‑cell lysates over time. Nuclear lysates of these α‑thrombin‑treated cells presented an increase in β‑catenin over time suggesting movement of β‑catenin into the nucleus. (C) When treated with α‑thrombin and SCH79797, MKN45/PAR1 and MKN74 cells present results similar to MKN45/mock cells. Equal loading of protein was confirmed with anti‑GAPDH antibody.
Sc 203693a, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sch+79797/SCH+79797+dihydrochloride/pmc09218513-46-5-2
Average 93 stars, based on 1 article reviews
sc 203693a - by Bioz Stars, 2026-09
93/100 stars
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sch 79797  (Schering-Plough corporation)
90
Schering-Plough corporation sch 79797
Figure 1. Protease‑activated receptor‑1 <t>(PAR1)</t> activation-dependent expression of epithelial‑mesenchymal transition (EMT) markers in MKN45/PAR1 and MKN74 cells. Whole‑cell and nuclear‑cell lysates of MKN45/mock, MKN45/PAR1 and MKN74 cells were probed for EMT‑marker expression by western blotting. (A) EMT‑marker expression remains the same in MKN45/mock cells treated with α‑thrombin or α‑thrombin plus <t>SCH79797</t> for 24 h. (B) MKN45/PAR1 and MKN74 cells treated with α‑thrombin present decreased levels of E‑cadherin and β‑catenin and increased levels of fibronectin and vimentin in whole‑cell lysates over time. Nuclear lysates of these α‑thrombin‑treated cells presented an increase in β‑catenin over time suggesting movement of β‑catenin into the nucleus. (C) When treated with α‑thrombin and SCH79797, MKN45/PAR1 and MKN74 cells present results similar to MKN45/mock cells. Equal loading of protein was confirmed with anti‑GAPDH antibody.
Sch 79797, supplied by Schering-Plough corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sch+79797/sch+79797/10__1161_slash_circulationaha__108__766063-4-0-12
Average 90 stars, based on 1 article reviews
sch 79797 - by Bioz Stars, 2026-09
90/100 stars
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sch-79797  (Verlag GmbH)
90
Verlag GmbH sch-79797
Figure 1. Protease‑activated receptor‑1 <t>(PAR1)</t> activation-dependent expression of epithelial‑mesenchymal transition (EMT) markers in MKN45/PAR1 and MKN74 cells. Whole‑cell and nuclear‑cell lysates of MKN45/mock, MKN45/PAR1 and MKN74 cells were probed for EMT‑marker expression by western blotting. (A) EMT‑marker expression remains the same in MKN45/mock cells treated with α‑thrombin or α‑thrombin plus <t>SCH79797</t> for 24 h. (B) MKN45/PAR1 and MKN74 cells treated with α‑thrombin present decreased levels of E‑cadherin and β‑catenin and increased levels of fibronectin and vimentin in whole‑cell lysates over time. Nuclear lysates of these α‑thrombin‑treated cells presented an increase in β‑catenin over time suggesting movement of β‑catenin into the nucleus. (C) When treated with α‑thrombin and SCH79797, MKN45/PAR1 and MKN74 cells present results similar to MKN45/mock cells. Equal loading of protein was confirmed with anti‑GAPDH antibody.
Sch 79797, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sch+79797/sch+79797/pm24338998-139-3-10
Average 90 stars, based on 1 article reviews
sch-79797 - by Bioz Stars, 2026-09
90/100 stars
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sch 79797  (Cayman Chemical)
N/A
SCH 79797 is a non peptide antagonist of proteinase activated receptor 1 PAR1 It blocks binding of the high affinity thrombin receptor activating peptide haTRAP IC 70 nM as well as platelet aggregation induced by
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sch 79797 dihydrochloride  (Toronto Research Chemicals)
N/A
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sch-79797  (Aladdin Scientific Corporation)
N/A
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sch 79797 dihydrochloride  (BOC Sciences)
N/A
SCH 79797 dihydrochloride is a potent and selective non-peptide PAR1 receptor antagonist (IC50 = 70 nM). SCH 79797 blocks haTRAP-induced human platelet aggregation. It also inhibits PAR1 agonist- or thrombin-induced increases in cytosolic Ca2+ in
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Image Search Results


Figure 1. Protease‑activated receptor‑1 (PAR1) activation-dependent expression of epithelial‑mesenchymal transition (EMT) markers in MKN45/PAR1 and MKN74 cells. Whole‑cell and nuclear‑cell lysates of MKN45/mock, MKN45/PAR1 and MKN74 cells were probed for EMT‑marker expression by western blotting. (A) EMT‑marker expression remains the same in MKN45/mock cells treated with α‑thrombin or α‑thrombin plus SCH79797 for 24 h. (B) MKN45/PAR1 and MKN74 cells treated with α‑thrombin present decreased levels of E‑cadherin and β‑catenin and increased levels of fibronectin and vimentin in whole‑cell lysates over time. Nuclear lysates of these α‑thrombin‑treated cells presented an increase in β‑catenin over time suggesting movement of β‑catenin into the nucleus. (C) When treated with α‑thrombin and SCH79797, MKN45/PAR1 and MKN74 cells present results similar to MKN45/mock cells. Equal loading of protein was confirmed with anti‑GAPDH antibody.

Journal: International journal of oncology

Article Title: Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer.

doi: 10.3892/ijo.2014.2651

Figure Lengend Snippet: Figure 1. Protease‑activated receptor‑1 (PAR1) activation-dependent expression of epithelial‑mesenchymal transition (EMT) markers in MKN45/PAR1 and MKN74 cells. Whole‑cell and nuclear‑cell lysates of MKN45/mock, MKN45/PAR1 and MKN74 cells were probed for EMT‑marker expression by western blotting. (A) EMT‑marker expression remains the same in MKN45/mock cells treated with α‑thrombin or α‑thrombin plus SCH79797 for 24 h. (B) MKN45/PAR1 and MKN74 cells treated with α‑thrombin present decreased levels of E‑cadherin and β‑catenin and increased levels of fibronectin and vimentin in whole‑cell lysates over time. Nuclear lysates of these α‑thrombin‑treated cells presented an increase in β‑catenin over time suggesting movement of β‑catenin into the nucleus. (C) When treated with α‑thrombin and SCH79797, MKN45/PAR1 and MKN74 cells present results similar to MKN45/mock cells. Equal loading of protein was confirmed with anti‑GAPDH antibody.

Article Snippet: The selective PAR1 antagonist Sch79797 (catalog no. 1592) (ic50=70 nM) was purchased from tocris Bioscience (avonmouth, uK) (25).

Techniques: Activation Assay, Expressing, Western Blot

Figure 2. Fluorescence immunocytochemical staining of fibronectin and E‑cadherin in MKN45/mock, MKN45/PAR1 and MKN74 cells, when treated with α‑thrombin or α‑thrombin plus SCH79797. (A) MKN45/mock cells present no significant changes in fibronectin and E‑cadherin expression. (B) MKN45/APR1 and MKN74 cells treated with α‑thrombin presented a decreased level of E‑cadherin expression and an enhanced level of fibronectin expression. (C) MKN45/APR1 and MKN74 cells treated with α‑thrombin and SCH79797, presented fibronectin and E‑cadherin expression levels similar to that of untreated cultures of these cells.

Journal: International journal of oncology

Article Title: Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer.

doi: 10.3892/ijo.2014.2651

Figure Lengend Snippet: Figure 2. Fluorescence immunocytochemical staining of fibronectin and E‑cadherin in MKN45/mock, MKN45/PAR1 and MKN74 cells, when treated with α‑thrombin or α‑thrombin plus SCH79797. (A) MKN45/mock cells present no significant changes in fibronectin and E‑cadherin expression. (B) MKN45/APR1 and MKN74 cells treated with α‑thrombin presented a decreased level of E‑cadherin expression and an enhanced level of fibronectin expression. (C) MKN45/APR1 and MKN74 cells treated with α‑thrombin and SCH79797, presented fibronectin and E‑cadherin expression levels similar to that of untreated cultures of these cells.

Article Snippet: The selective PAR1 antagonist Sch79797 (catalog no. 1592) (ic50=70 nM) was purchased from tocris Bioscience (avonmouth, uK) (25).

Techniques: Fluorescence, Staining, Expressing

Figure 3. Electrophoretic mobility shift assays (EMSAs), demonstrate specific interaction with the E‑cadherin promoter. (A) EMSAs were performed with nuclear extracts from MKN45/mock and MKN74 cells and demonstrate an E‑cadherin E‑box 1‑3 nuclear protein complex. No levels of specific E‑box complexes are seen in MKN45/mock and MKN74 cells. These cells are the control. (B) These lanes show nuclear extracts from MKN45/PAR1 and MKN74 cells, treated with α‑thrombin for 12 h, and demonstrate an E‑cadherin E‑box1‑3 nuclear protein complex. Higher levels of specific E‑box complexes are seen in MKN45/PAR1 and MKN74 cells treated with α‑thrombin that overexpress relative to control cells. (C) Specific complexes were inhibited by protease‑activated receptor‑1 (PAR1) selective antagonist SCH79797.

Journal: International journal of oncology

Article Title: Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer.

doi: 10.3892/ijo.2014.2651

Figure Lengend Snippet: Figure 3. Electrophoretic mobility shift assays (EMSAs), demonstrate specific interaction with the E‑cadherin promoter. (A) EMSAs were performed with nuclear extracts from MKN45/mock and MKN74 cells and demonstrate an E‑cadherin E‑box 1‑3 nuclear protein complex. No levels of specific E‑box complexes are seen in MKN45/mock and MKN74 cells. These cells are the control. (B) These lanes show nuclear extracts from MKN45/PAR1 and MKN74 cells, treated with α‑thrombin for 12 h, and demonstrate an E‑cadherin E‑box1‑3 nuclear protein complex. Higher levels of specific E‑box complexes are seen in MKN45/PAR1 and MKN74 cells treated with α‑thrombin that overexpress relative to control cells. (C) Specific complexes were inhibited by protease‑activated receptor‑1 (PAR1) selective antagonist SCH79797.

Article Snippet: The selective PAR1 antagonist Sch79797 (catalog no. 1592) (ic50=70 nM) was purchased from tocris Bioscience (avonmouth, uK) (25).

Techniques: Electrophoretic Mobility Shift Assay, Control

Figure 4. Snail detected in nuclear lysate. The impact of α‑thrombin treatment of MKN45/PAR1 and MKN74 cells upon nuclear localization of transcription factors in these cells (Twist, Snail and E12/E47) was profiled by means of western blotting. Twist and E12/E47 were not able to migrate into the nucleus, when treated with α‑thrombin while Snail was able to do so, when these cells were treated with α‑thrombin for 12 h.

Journal: International journal of oncology

Article Title: Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer.

doi: 10.3892/ijo.2014.2651

Figure Lengend Snippet: Figure 4. Snail detected in nuclear lysate. The impact of α‑thrombin treatment of MKN45/PAR1 and MKN74 cells upon nuclear localization of transcription factors in these cells (Twist, Snail and E12/E47) was profiled by means of western blotting. Twist and E12/E47 were not able to migrate into the nucleus, when treated with α‑thrombin while Snail was able to do so, when these cells were treated with α‑thrombin for 12 h.

Article Snippet: The selective PAR1 antagonist Sch79797 (catalog no. 1592) (ic50=70 nM) was purchased from tocris Bioscience (avonmouth, uK) (25).

Techniques: Western Blot